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Intra-operatively Fitted Antibiotic Spacer Construct for Periprosthetic Joint Infection (PJI) Treatment

Researchers at UTHealth have created a novel weight-bearing articular antibiotic spacer to address the known limitations of standard PJI treatment while improving its potential to be a one-stage revision. The intra-operatively shapeable antibiotic spacer construct is incorporated with additional capabilities to treat bone defects while preserving host...

Published: 2/18/2025 | Inventor(s): Kenneth Mathis, Hugh Jones, Ethan Sij

Keywords(s):

Category(s): Medical Devices

Pharmacological EZH2 inhibition enhances cancer cell sensitivity to genotoxic insults through suppressing DNA damage repair

HSC-1535 Pharmacological EZH2 inhibition enhances cancer cell sensitivity to genotoxic insults through suppressing DNA damage repairKexin Xu: Department of Molecular Medicine, University of Texas Health Science Center at San Antonio, San Antonio, TX 78229, USA.Myles Brown: Center for Functional Cancer Epigenetics and Department of Medical Oncology,...

Published: 1/13/2025 | Inventor(s): Kexin Xu, Myles Brown, Chen-Hao Chen, Xiaole Shirley Liu, CPRIT

Keywords(s):

Category(s): Clinical Specialty > Oncology, Clinical Specialty > Radiology, Diagnostics > Assay, Life Sciences Research Tools > Biomarkers

Efficient & Broadband Even-Order Harmonic Multiplication in Standard CMOS

A novel technique to realize highly-efficient passive multipliers in a standard CMOS process is demonstrated to efficiently generate even-order harmonics while simultaneously suppressing odd-order harmonics over broad-bandwidths. This is achieved by improving the cutoff frequency (fT) well beyond a THz. The higher fT combined with proposed nonlinearity...

Published: 4/26/2019 | Inventor(s): Kenneth O, Zeshan Ahmad

Keywords(s): Devices, Electronics, Engineering & Physical Sciences, Imaging, Optics & Photonics, Semiconductor, MEMS & Nanotechnology, Signal Processing, Wireless

Category(s): Communications

Novel Nitric Oxide Releasing Surgical Sutures, Bandages and Fabrics

Non-Confidential DescriptionThe technology is novel nitric oxide (NO) releasing acrylonitrile-based copolymer and terpolymer fibers that can be used as surgical sutures or non-woven bandages and fabrics that enhance wound healing. These copolymers have a higher NO loading capacity per gram than other known NO releasing acrylonitrile polymers. In addition,...

Published: 4/26/2019 | Inventor(s): Kenneth Balkus, Alysia Lowe, Dennis Smith, Wenjin Deng

Keywords(s): Biocompatible, Drug Delivery, Healthcare, Life Sciences, Materials, Medical, Medical Devices, Polymers, Textiles, Therapeutics

Category(s): Healthcare

A Method of Storage and Controlled Delivery of Nitric Oxide

Invention:The invention is unique Titanium dioxide nanotubes decorated with NO releasing groups to store and deliver NO using photochemical methods in both external and internal medical treatments. It provides a method of storing NO that can be delivered to targeted spaces and a controlled photodynamic activation process that eliminates any potential...

Published: 6/29/2024 | Inventor(s): Kenneth Balkus, Chalita Ratanatawanate

Keywords(s): Biocompatible, Chemistry, Drug Delivery, Engineering & Physical Sciences, Materials, Medical Devices, Textiles, Therapeutics

Category(s): Biomedical, Nanotechnology, Healthcare

A Method of Nitric Oxide Delivery for Healing and Organ Preservation

Invention:The invention is a medical device, more specifically a bandage, which releases Nitric Oxide to help heal wounds, improve blood circulation and preserve organs being stored for transplant.Nitric Oxide opens blood vessels and keep them relaxed, two of the key factors that help blood flow. Secondly this device inhibits thrombosis thereby preserving...

Published: 6/29/2024 | Inventor(s): Kenneth Balkus, Harvey Liu, Chalita Ratanatawanate

Keywords(s): Biocompatible, Chemistry, Devices, Drug Delivery, Engineering & Physical Sciences, Healthcare, Medical, Medical Devices, Therapeutics

Category(s): Materials, Biomedical