Latest technologies from Texas Portalhttp://texas.technologypublisher.comBe the first to know about the latest inventions and technologies available from Texas Portalen-USSat, 19 Aug 2017 13:35:41 GMTFri, 18 Aug 2017 08:06:30 GMT 2017, Texas PortalTrick of the Light: High Performance Light Emitting Devices from Ionic Transition Metal Complexes a high lighting efficiency is critical for energy and environmental conservation efforts around the world. Since lighting attributes to 11% of energy usage in residential buildings and 18% in commercial buildings, improving its efficiency as a whole could have a beneficial effect on the general populace and drastically reduce costs for individuals using and supplying lighting. Because energy production is one of the most prominent contributors to greenhouse gas emissions, improving lighting performance could slow climate change and dampen future expenses associated with reversing env...Fri, 18 Aug 2017 08:06:30 GMTbrent.schultze@utdallas.edu Plasticity and Recovery Following Spinal Cord Injury, 14 Aug 2017 08:35:37 GMTbrent.schultze@utdallas.edu Passive RFID Systems, 24 Jul 2017 08:41:08 GMTbrent.schultze@utdallas.edu Power Feedback for Extremum Seeking Control of Wind Turbines a wind turbine operates between the cut-in and rated wind speeds, the machine is controlled to maximize wind energy capture. The extremum seeking control (ESC) algorithm has been proposed to locate and track the optimal operating condition for power maximization. This is accomplished by applying the ESC to the power signal to determine optimal values for parameters of the control law or actuator settings. Since the power signal is proportional to the cube of the mean wind speed, changes in wind conditions may lead to significant variations in the performance of the ESC algorithm. This pap...Fri, 14 Jul 2017 11:51:10 GMTbrent.schultze@utdallas.edu System for Label-Free Analysis of Binding Kinetics for Multiple Analytes are numerous problems faced with many of the standard biomolecular analysis tools, such as limited sensitivity, expensive set-up and per-test necessities, and space requirements that have prohibited their use outside of a dedicated laboratory space. The need for a portable and inexpensive diagnostic tool that can be customized for various target analytes has been shown. Such a device would revolutionize testing at the point of care for healthcare applications, or serve numerous purposes for rapid on-demand analysis of biomolecules in the environment. The disclosed Multielectrode Array (M...Fri, 07 Jul 2017 10:43:21 GMTbrent.schultze@utdallas.edu Electrochemical Impedance System for Universal Molecular Diagnostics methods of producing molecular diagnostic tools have many drawbacks, such as: the high-cost of fabrication, poor biodegradability, limited customizability, or issues with controlled fluid flow. Such problems have limited the ability to create portable detection devices for use in point-of-care settings that use environmentally-safe disposable parts. The present invention uses paper-based microfluidics and handheld potentiostats to detect biomolecules and other target analytes. This device has the capability to revolutionize testing at the point of care for healthcare applications, or c...Fri, 07 Jul 2017 10:42:43 GMTbrent.schultze@utdallas.edu Dental Abutment Geometries for Cement-Retained Crowns, 05 Jun 2017 08:45:06 GMTbrent.schultze@utdallas.edu Site Identification Method and Apparatus, 01 Jun 2017 14:59:24 GMTuthsch-otm@uth.tmc.edu Textiles Prepared from Nanofiber Yarns and Polymer Fiber Actuators, 30 May 2017 09:06:49 GMTbrent.schultze@utdallas.edu Thermoacoustic Projector Based on Free-Standing Carbon Nanotube Film, 26 May 2017 07:52:30 GMTbrent.schultze@utdallas.edu Solution for Selective Adsorption and Release of Gases Within Porous Materials, 26 May 2017 07:37:15 GMTbrent.schultze@utdallas.edu Nanoparticle Drug Delivery Systems, 23 May 2017 14:45:16 GMTuthsch-otm@uth.tmc.edu Solid-State Organic Semiconductors, 27 Apr 2017 11:08:31 GMTbrent.schultze@utdallas.edu Environmentally Friendly Solution for Preservation and Increased Nutritional Value of Hay and Forage, 24 Apr 2017 13:41:09 GMTbrent.schultze@utdallas.edu New Environmentally Friendly Acid for Hydrolysis of Celluloses, 24 Apr 2017 13:41:07 GMTbrent.schultze@utdallas.edu System for Compliance with Congestive Heart Failure (CHF) Management Guidelines, 24 Apr 2017 13:41:05 GMTbrent.schultze@utdallas.edu Massive MIMO System and Capacity Adaptation Between Uplink and Downlink, 19 Apr 2017 08:40:10 GMTbrent.schultze@utdallas.edu pot difunctionalization of hyaluronic acid with thiol and azide groups, 14 Apr 2017 09:50:09 GMTuthsch-otm@uth.tmc.edu, 14 Apr 2017 07:51:23 GMTuthsch-otm@uth.tmc.edu of Bone Regeneration Scaffolds and Bone Filler Material Using a Perfusion Flow System, 07 Apr 2017 08:28:45 GMTsaenzv@uthscsa.edu Scaffold Culture System of Functional Pancreatic Islets, 07 Apr 2017 08:19:47 GMTsaenzv@uthscsa.edu Device for Dynamic Allodynia Testing, 02 Mar 2017 14:47:01 GMTbrent.schultze@utdallas.edu Immiscible Polymer Blends and Molecular Sieve Membranes, 21 Feb 2017 13:34:20 GMTbrent.schultze@utdallas.edu Peptide based Delivery System to Target Delivery of Antibacterial Agents (Targeting a Quorum Sensing System) emergence of drug-resistant pathogens is a global concern for human health, in the United States at least 2 million people become infected with antibiotic resistant bacteria and it leads to the death of at least 23,000 people per year. Exemplary bacteria are rapidly developing resistance against various antibiotics. Therefore, while continual exploration for novel antibiotics is needed, establishment of alternative antimicrobial strategies based on non-traditional mechanisms is an unmet need in the medical field. Inventors at the University of Texas Health Science Center have developed an ...Tue, 14 Feb 2017 07:40:20 GMTuthsch-otm@uth.tmc.edu Fibers for Superelastic Electronics, Sensors, and Muscles, 03 Feb 2017 12:42:48 GMTbrent.schultze@utdallas.edu fluorinated proton exchange membranes based on PFCP for fuel cell membranes Description:There is currently a lack of commercially available proton exchange membranes that can withstand the harsh operating conditions of a fuel cell. Commercially available membranes work well under specific temperature and humidity conditions, however their utility is drastically reduced at higher temperatures and lower relative humidity. Researchers at The University of Texas at Dallas have developed membranes that demonstrate the desired properties of a fuel cell membrane: superior conductance and high stability under high temperatures and lower humidity. By blending hydrop...Fri, 13 Jan 2017 14:41:42 GMTbrent.schultze@utdallas.edu Torque Density Switched Reluctance Motors, 13 Jan 2017 14:41:42 GMTbrent.schultze@utdallas.edu of bioactivity and antibiotics in two-solution bone cement, 13 Jan 2017 14:41:40 GMTbrent.schultze@utdallas.edu Ionic liquids for Surface Modification of Dental Implants, 13 Jan 2017 14:41:40 GMTbrent.schultze@utdallas.edu Lower-Limb Prosthetic Control Strategy, 19 Dec 2016 12:55:45 GMTbrent.schultze@utdallas.edu antibodies against EGFL6 for diagnostic and cancer therapeutic use, 06 Sep 2016 09:20:37 GMTuthsch-otm@uth.tmc.edu Channelrhodopsins for Inhibition of Neuronal Activity is rapidly evolving field that provides the ability to control neurons using light-sensitive proteins called channelrhodopsins (ChRs). When genetically expressed in neurons, ChRs have the ability to selectively manipulate neuronal activity in a light-dependent manner. Gene-therapy using ChRs has the exciting potential to be used to treat patients suffering from disorders caused by aberrant neuronal signaling. Dr. John L. Spudich and his research team have disrupted the field of optogenetics through their discovery and development of first of their kind anion channelrhodopsins (ACR...Wed, 13 Jul 2016 13:16:39 GMTuthsch-otm@uth.tmc.edu (Cx)43 Hemichannel-Binding Antibodies And Uses Thereof, 17 Jun 2016 14:32:51 GMTuthsch-otm@uth.tmc.edu Nanoparticles for Site-specific, Sequential Drug Delivery nested nanoparticles for drug delivery have been developed at UTHealth to deliver multiple drugs in a site-, time-, and sequence-specific manner. These nanoparticles consist of a drug-containing polymeric core made of PLGA, surrounded by an outer shell of cyclodextrin complexed with a second drug. These two delivery components facilitate dual-release kinetics, and have been shown in vivo to be efficacious at inhibiting tumor growth compared to controls. These nanoparticles have been designed for site-specific delivery of cancer therapeutics to tumors but have broad applicability, including...Tue, 24 May 2016 15:00:52 GMTuthsch-otm@uth.tmc.edu Mitral Valve Repair Simulation, 07 Apr 2016 14:43:50 GMTuthsch-otm@uth.tmc.edu Compounds for the Prevention and Treatment of Clostridium difficile Infections, 28 Jan 2016 12:20:52 GMTuthsch-otm@uth.tmc.edu Understanding in an Ontology Driven Platform, including Data Collection and Processing ABSTRACT Systems and method to aid in the collection, representation and mining of data are disclosed. More particularly, embodiments as disclosed may utilize a unifying format to represent data obtained or utilized by a system to facilitate linking between data from different sources and the commensurate ability to mine such data. Specifically, embodiments may represent data as graphs that comprise the concepts and relationships between those concepts. In this manner, concepts in graphs that represent distinct groupings of data may be mapped and knowledge mining with respect to these graphs ...Fri, 13 Nov 2015 12:32:54 GMTuthsch-otm@uth.tmc.edu Optic Probe for Deep Non-Invasive Raman Spectroscopy, 06 Nov 2015 13:13:47 GMTuthsch-otm@uth.tmc.edu culture media with prostaglandin or its analog to enhance the development of embryos, 05 Nov 2015 12:23:11 GMTuthsch-otm@uth.tmc.edu Language Annotation, Language Modeling and Processing Toolkit (CLAMP), 29 Sep 2015 11:33:57 GMTuthsch-otm@uth.tmc.edu Conversations and Explanations, 24 Aug 2015 09:40:43 GMTuthsch-otm@uth.tmc.edu particles responding to hypoglycemia, 05 Aug 2015 11:23:41 GMTuthsch-otm@uth.tmc.edu to Produce Novel Analgesic Drugs, 04 May 2015 12:23:27 GMTsaenzv@uthscsa.edu Micro RNA as a Tumor Suppressor, 23 Apr 2015 14:29:19 GMTsaenzv@uthscsa.edu hamstring stretching device to treat lower back pain, 23 Apr 2015 13:48:30 GMTsaenzv@uthscsa.edu Cancer Therapeutic: TGF-beta Trap, 21 Apr 2015 11:13:06 GMTsaenzv@uthscsa.edu ATP for Treatment of Primary and Metastatic Cancer, 16 Apr 2015 12:02:50 GMTsaenzv@uthscsa.edu Sensitive Foley Catheter Alarm, 16 Apr 2015 11:53:55 GMTsaenzv@uthscsa.edu of Capsazepine and Analogs for Treatment of Cancer, 16 Apr 2015 08:40:56 GMTsaenzv@uthscsa.edu Vivo Methods to Induce Pancreatic Beta Cell Formation for Treatment of Diabetes, 13 Apr 2015 10:37:28 GMTsaenzv@uthscsa.edu as Novel Therapeutic Adjuvants and Biomarkers for Drug Resistant Breast Cancers, 10 Apr 2015 14:22:45 GMTsaenzv@uthscsa.edu Proteasome Inhibitors for Treatment of Cancer, 10 Apr 2015 10:08:55 GMTsaenzv@uthscsa.edu and Platform for Selectively Labeling RNA invention pertains to a three step initiation, elongation and termination method and platform for synthesizing selectively labeled RNA molecules by first polymerizing a first liquid phase RNA molecule from a solid phased DNA template fixed onto a solid phase. The method includes the steps of incubating the solid and liquid phases at appropriate elongation temperatures and then terminating elongation by a separation stage where the phases are incubated at near 0 degrees Celsius where it selectively terminates RNA elongation. The steps can be repeated by the number bases (rNTPs) in the fina...Fri, 10 Apr 2015 08:58:34 GMTsaenzv@uthscsa.edu Protective Pneumococcal Vaccine with Cardiac Protection the emergence of pneumococcal infections caused by non-vaccine serotypes and multidrug resistant strains, this broadly effective vaccine may be the best strategy for decreasing morbidity and mortality. Because it also protects against adverse cardiac events during and after pneumococcal pneumonia, it has strong potential as a vaccine for seniors who already have cardiovascular disease and it provides an additional indication for a pneumococcal vaccine outside of the current vaccine recommendations. Phase 1 clinical study is ongoing. This novel indication is part of a portfolio created in ...Fri, 10 Apr 2015 08:49:24 GMTsaenzv@uthscsa.edu Thin-Film Capacitive Sensor with Multiple Applications, 10 Apr 2015 08:43:48 GMTsaenzv@uthscsa.edu and Composition for Inhibiting Proto-Oncogene PELP1, 10 Apr 2015 07:31:08 GMTsaenzv@uthscsa.edu Associated 5-ASA for the Treatment of Inflammatory Bowel Disease Inflammatory Bowel Disease (IBD) which represents a spectrum of diseases of the lower GI tract, notably Ulcerative Colitis (UC) and Crohn’s Disease (CD), is one of the most common gastrointestinal (GI) afflictions in the United States and Europe. It is also noteworthy that the incidence of UC has increased 2-3 fold in China and other counties in Asia adopting a more Westernized diet/lifestyle over the past decade. It has been estimated by the CDC that health care cost of $1.7 billion in the US are directly attributable to patients afflicted with UC and CD. When one includes los...Mon, 15 Sep 2014 11:14:44 GMTuthsch-otm@uth.tmc.edu, Small-Size Multi-String LED Driver Circuit Architecture, 06 Aug 2014 14:03:33 GMTbrent.schultze@utdallas.edu Escherichia coli Isolates Identified from Patients with Travelers' Diarrhea, 24 Jun 2014 13:08:22 GMTuthsch-otm@uth.tmc.edu Microspheres For Treatment Of Infections And Osteomyelitis, 20 Mar 2014 08:54:25 GMTuthsch-otm@uth.tmc.edu and stabilization for foot and ankle surgery in diabetic patients, 14 Jan 2014 07:44:27 GMTsaenzv@uthscsa.edu matrix for intracorporeal biosensors that improves gastrointestinal leak detection, detects air leaks after lung surgery, and measures cardiac output after heart surgery, 18 Dec 2013 08:19:53 GMTsaenzv@uthscsa.edu Cervical Ripening System (ACRS), 17 Dec 2013 13:40:49 GMTsaenzv@uthscsa.edu and Apparatus for Transferring an Array of Oriented Carbon Nanotubes, 07 Jun 2013 13:59:21 GMTbrent.schultze@utdallas.edu Novel Quantitative Low-Light Imaging Modality That Enables Near-Best Parameter Estimation Accuracies, 01 May 2013 12:49:18 GMTbrent.schultze@utdallas.edu compounds from invasive salvinias (Salvinia spp.) against human tumor cells, 23 Apr 2013 10:12:37 GMTsaenzv@uthscsa.edu Inhibitors of Reactive Oxygen Species (ROS) Production, 11 Apr 2013 09:59:49 GMTsaenzv@uthscsa.edu Device and Methods for Image Alignment in Cone Beam CT, Dental Radiography and Digital Subtraction, 11 Apr 2013 09:59:47 GMTsaenzv@uthscsa.edu Compounds and Methods of Use for the Treatment and Prevention of Cancer via Inhibition of the K-Ras Pathway, 02 Apr 2013 13:33:12 GMTuthsch-otm@uth.tmc.edu and Apparatus for Stent Deployment with Enhanced Delivery of Bio-Active Agents, 04 Mar 2013 09:50:16 GMTsaenzv@uthscsa.edu Class of pH Responsive and Renal Clearable Tumor Imaging Agents, 26 Feb 2013 14:36:00 GMTbrent.schultze@utdallas.edu Nitric Oxide Releasing Surgical Sutures, Bandages and Fabrics DescriptionThe technology is novel nitric oxide (NO) releasing acrylonitrile-based copolymer and terpolymer fibers that can be used as surgical sutures or non-woven bandages and fabrics that enhance wound healing. These copolymers have a higher NO loading capacity per gram than other known NO releasing acrylonitrile polymers. In addition, the fibers are coated with biodegradable polymers that allow for the timed, slow release of NO when the suture, bandage or fabric is in contact with the wound. These fibers have a long shelf life and when used in wound closure applications ha...Tue, 26 Feb 2013 13:57:55 GMTbrent.schultze@utdallas.edu, Small-Size Multi-String LED Driver Circuit Architecture, 25 Feb 2013 14:01:34 GMTbrent.schultze@utdallas.edu Automatic Tuning of Noise Suppression for Cochlear Implants and Hearing Aids, 25 Feb 2013 13:11:27 GMTbrent.schultze@utdallas.edu method to better predict the likelihood that endocrine therapy alone after surgical intervention will be sufficient to treat patients with estrogen-receptor-positive breast cancer, 07 Feb 2013 13:30:05 GMTsaenzv@uthscsa.edu and Methods for Regulation of Stem Cell Survival, Proliferation, and Differentiation, 09 Jan 2013 11:10:45 GMTuthsch-otm@uth.tmc.edu"Pedinap" - A Pediatric Anesthesia/Pharmacological Agent Induction Device, 10 Dec 2012 15:41:06 GMTuthsch-otm@uth.tmc.edu Port Security And Access Control Software, 05 Dec 2012 07:10:22 GMTuthsch-otm@uth.tmc.edu High-Efficiency System for in vitro and in vivo Biotinylation, 26 Sep 2012 12:53:58 GMTsaenzv@uthscsa.edu Bridging the Semantic Gap in Virtual Machine Introspection, 15 Aug 2012 12:06:21 GMTbrent.schultze@utdallas.edu Method for Near-Best Signal Throughput in Mobile Wireless Communications, 15 Aug 2012 11:30:22 GMTbrent.schultze@utdallas.edu and Use of Alveoar Cells to Treat Lung Disorders, 23 Jul 2012 14:58:53 GMTuthsch-otm@uth.tmc.edu Red Shifted Channelrhodopsins with Rapid Kinetics, 15 Jun 2012 15:33:46 GMTuthsch-otm@uth.tmc.edu Method for Greatly Increasing Liposomal Drug Delivery to Lymph Nodes, 30 May 2012 09:00:30 GMTsaenzv@uthscsa.edu Needle Biopsy, 30 May 2012 09:00:28 GMTsaenzv@uthscsa.edu Nanopowders and Carbon nanotube Sheets into Fibers, Yarns and Textiles Description:The technology is the first known method to spin biscrolled fibers/yarns from nanopowder materials using carbon nanotube (CNT) sheets as the host. Nanopowder materials (nanoparticles, nanofibers) are loaded onto the CNT sheets to form bi-layered sheets, which are then scrolled into fibers. A key advantage of this technology is that it enables the functional nanopowder to be the largest component of the yarns constituting 95-99% (by weight) of the yarn, thereby ensuring that the properties exhibited by the yarn are largely those of the nanopowder. Nanopowders with d...Wed, 14 Mar 2012 14:05:20 GMTbrent.schultze@utdallas.edu Monoclonal Antibodies, 05 Jan 2012 12:30:18 GMTuthsch-otm@uth.tmc.edu and Prevention of Vascular Disease with Hybrid Cyclooxygenase:Eicosanoid Proteins Market: Some form of vascular disease effects one in four Americans, and costs for treatment reach into the billions. Prostanoids are an important, and emerging, therapeutic target in the campaign against vascular disease. Competitors and Current Problems: The prostanoid synthesis pathway is complicated, difficult to direct, and can have multiple end results, not all of them favorable. For example, some of the recent issues in the media and scientific community surrounding COX-2 inhibitors (such as increased potential of heart attacks among patients on COX-2 inhibitors) may involve u...Tue, 29 Nov 2011 09:53:17 GMTuthsch-otm@uth.tmc.edu Tumors by Pattern Recognition: A Paradigm shift in Targeted Therapeutics Market: The American Cancer Society estimates that more than 500,000 people will die from cancer in the U.S. in 2007. Many cancer deaths, specifically from cancers of the colon, breast, rectum, and uterine cervix cancers, could be significantly reduced with earlier detection and improved therapy. Cancer treatment of the 15 most common cancers accounted for an estimated $72.1 billion of medical expenditures in the US in 2004. World wide, IMS Health reported that drug companies exceeded $34 billion in sales of cancer drugs in 2006. Competitors and Current Problems: The holy grail of can...Tue, 29 Nov 2011 09:53:16 GMTuthsch-otm@uth.tmc.edu Protease Nucleotides and Proteins for Diagnosing Hyperpoliferative Diseases Prostate cancer is the second most common cancer, and second leading cause of cancer death, in American men. The American Cancer Society predicts over 186,000 new diagnoses of prostate cancer, and over 28,000 deaths in the US in 2008. With early detection being key to a better prognosis, a significant number of people are demanding faster and more accurate diagnosis, and more targeted, efficient, and effective therapies. Competitors and Current Problems: One diagnostic of prostate cancer is by the PSA blood tests. Unfortunately, if higher than normal levels of PSA are detected ...Tue, 29 Nov 2011 09:53:16 GMTuthsch-otm@uth.tmc.edu of Proline- and Arginine-Rich Peptides that Lead to Inhibition of Inflammation and Induction of Angiogenesis Technology: PR39, a naturally produced proline-and-arginine-rich peptide consisting of 39 amino acids, induces angiogenesis and reduces inflammation in mouse models. Through structural and biochemical investigations of PR11, a truncated form of PR39, researchers at the University of Texas Health Science Center at Houston (UTHSC-H) have identified that the 20S proteasome-inhibiting activity of PR39 depends on specific amino acids and structural characteristics. They have also discovered a novel 12-amino acid peptide that has comparable activity as PR39. The linear amino acid sequenc...Tue, 29 Nov 2011 09:53:15 GMTuthsch-otm@uth.tmc.edu From Shock Market: The Clinical Decision Support System (CDSS) market in Europe alone is estimated to grow to near $430.7 billion by 2012. The American Hospital Association (AHA) reported in a 2006 survey that the number of hospitals adopting moderate to high use of IT systems in general increased 37% from 2005. With more than $37 million patient admissions in 2006 to AHA registered hospitals, the market for increased IT adoption, including CDSS, has very lucrative potential. Competitors and Current Problems: Shock resuscitation after severe injury and blood loss is an emergent effort to regain normal h...Tue, 29 Nov 2011 09:53:13 GMTuthsch-otm@uth.tmc.edu Cells for Treatment Of Ischemia Peripheral artery disease affects 8-12 million Americans. Patients experience pain, numbness, and ulcers. Mobility can be affected, and gangrene can set in. It is estimated that there are 150,000 amputations each year in the United States is due to critical leg ischemia. Of those, the peri-operative mortality rate for below the knee amputations is 5-10%, with a 15-20% peri-operative mortality rate for above the knee amputations. In addition, it is estimated that 30% of first time amputees will require a second amputation. Further, patients with critical limb ischemia have an el...Tue, 29 Nov 2011 09:53:11 GMTuthsch-otm@uth.tmc.edu Graft Scaffolds with High-Strength and High-Porosity, 29 Nov 2011 09:53:11 GMTuthsch-otm@uth.tmc.edu Polyclonal Antibody Polyclonal Antibodies Against HRS The Technology: Dr. Andrew Bean at the University of Texas Health Science Center at Houston (UTHealth) has developed a polyclonal antibody to Hrs. Hrs is a protein that plays a role in the growth factor signaling pathways. Cellular expression of hrs-2 can be determined via the polyclonal Hrs antibody. This antibody will be useful in determining the relationship between growth factor receptor tyrosine kinases and tyrosine phosphorylation of Hrs. Publications:• Growth factor-induced tyrosine phosphorylation of Hrs, a novel 115-kilodalton protein with a...Thu, 03 Nov 2011 09:50:43 GMTuthsch-otm@uth.tmc.edu of Cyclic Nucleotide Synthesis and Their Use Market: The over production of cyclic nucleotides such as cGMP and cAMP are critical factors in many diseases. The most common causes of diarrhea in humans and animals are mediated by elevated cGMP and are induced by toxins of pathogenic bacteria. The need for novel therapies for both the human and veterinary medical fields is tremendous. Diarrheal diseases are among the worlds leading causes of death, especially in children. The pathology resulting from edema factor of B. anthracis is mediated by cAMP and while antibiotics kill the organism itself, it is often the accumulated edema fa...Thu, 03 Nov 2011 09:50:00 GMTuthsch-otm@uth.tmc.edu Bisphosphonate Formulation with Therapeutic Use in Osteoporosis Market: There is a large market demand for therapeutic compounds addressing bone disease. Osteoporosis, osteitis deformans, or Paget?s disease, bone metastasis, multiple myeloma, and others result in bone fragility. It is noted that metastases to the bone occur in up to 75% of breast and prostate cancers. Of the above listed bone diseases, osteoporosis is a major indication with thirty-five million people in the seven major pharmaceutical markets (U.S., France, Germany, Italy, Spain, UK, and Japan) afflicted by osteoporosis. With this type of demand, it is not surprising that a recent analysi...Thu, 03 Nov 2011 09:49:12 GMTuthsch-otm@uth.tmc.edu of Lyme Disease, 03 Nov 2011 09:42:16 GMTuthsch-otm@uth.tmc.edu Method for Generating Poroelastograms in Vivo, 24 Oct 2011 09:15:59 GMTuthsch-otm@uth.tmc.edu of constitutively active soluble guanylyl cyclase (sGC) in prevention of cGMP-dependent pathophysiology and drug development Treatment Or Prevention Of Cgmp-Dependent Pathophysiology With A Mutant Variant Of A Soluble Guanylyl Cyclase Market: The technology has the potential to reach a multitude of markets, such as: cardiovascular disease, treatment and prevention of tumors, treatment of penile dysfunction, and treatment of septic shock. Competitors and Current Problems: It is known that soluble guanylyl cyclase (sGC) is an important enzyme that is involved in the regulation of cardiovascular homeostasis and pathologies (blood pressure, atherosclerosis, and septic shock), neurotransmission and sensory percep...Wed, 19 Oct 2011 08:27:05 GMTuthsch-otm@uth.tmc.edu Resistant and Dependent Cell Lines The Technology: Dr. Fernando Cabral at the University of Texas Health Science Center at Houston (UTHealth) has developed a series of mutant cell lines with altered sensitivity to antimitotic drugs. Paclitaxel is a drug that binds to polymerized tubulin and inhibits microtubule disassembly. One of the major limitations in using these drugs, however, is the emergence of drug resistant tumor cells. The inventor has found that some tubulin isotypes alter sensitivity to antimitotic drugs by perturbing microtubule assembly, while others have little effect on assembly but increase the binding...Wed, 19 Oct 2011 08:27:05 GMTuthsch-otm@uth.tmc.edu<![CDATA[OV-1 & OV-6 Hybridoma]]>, 19 Oct 2011 08:27:04 GMTuthsch-otm@uth.tmc.edu Embryonic Stem Cell Line EZ-BL6 Mouse Embryonic Stem Cell Line EZ-BL6 The Technology: Researchers at the University of Texas Health Science Center at Houston (UTHealth) have developed complement anaphylatoxin C5a-deficient mice via the disruption of the C5aR gene. It is becoming increasingly clear that C5aR plays an important role in the regulation of many physiological and cellular responses characteristic of acute shock and that the C3aR functions to temper the immune response in acute shock. This well-characterized model lacks the complement C5a, making it an excellent model for studying the relationship between C...Wed, 19 Oct 2011 08:27:04 GMTuthsch-otm@uth.tmc.edu Monoclonal Antibody Monoclonal Antibodies Against HRS-2 The Technology: Dr. Andrew Bean at the University of Texas Health Science Center at Houston (UTHealth) has developed a monoclonal antibody to Hrs-2. Hrs-2 is a protein that plays a role in the formation and dissolution of protein complexes during vesicular formation. Cellular expression of hrs-2 can be determined via the monoclonal hrs-2 antibody. This antibody will be useful in determining how hrs-2 is regulated and tracking hrs-2 interaction during vesicular trafficking. Publications:• The cellular and developmental expression of hrs-2 in rat. Eur...Wed, 19 Oct 2011 08:27:03 GMTuthsch-otm@uth.tmc.edu coli strain AD93/pTMG3 (lacking phosphatidylethanolamine (PE) and contain a-monoglucosyldiacylglycerol MGlcDAG)) Modified E. coli Strain AD93/pTMG3 The Technology: Dr. William Dowhan at the University of Texas Health Science Center at Houston (UTHealth) has developed a bacterial strain to construct null mutants in specific steps of phospholipid biosynthesis. The anionic phospholipid (phosphatidylglycerol and cardiolipin) content of the mitochondria can be varied and controlled in these mutants. This bacterial strain lacks phosphatidylethanolamine (PE) and contains monoglucosyldiacylglycerol. At present, the role of individual phospholipids in specific membrane functions is not completely underst...Wed, 19 Oct 2011 08:27:03 GMTuthsch-otm@uth.tmc.edu B KO Mouse on C57/BL/6 Genetic Background Factor B KO Mouse on C57/Bl/6 Genetic Background The Technology: Researchers at the University of Texas Health Science Center at Houston (UTHealth) have developed complement factor B-deficient mice on C57Black6 background via the disruption of the murine Bf, exon 3 through exon 7. It is becoming increasingly clear that factor B plays an important role in the regulation of the alternative complement pathway. The role of factor B in disease pathogenesis, however, is unclear. This well-characterized model lacks the complement factor B, making it an excellent model for studying the role of...Wed, 19 Oct 2011 08:27:02 GMTuthsch-otm@uth.tmc.edu coli strain JA200 carrying plasmid pPS3155-lambda (JA200/pPS3155-A) E. coli Strain JA200 Carrying Plasmid pPS3155-lambda The Technology: Dr. William Dowhan at the University of Texas Health Science Center at Houston (UTHealth) has developed a bacterial strain to construct null mutants in specific steps of phospholipid biosynthesis. The anionic phospholipid (phosphatidylglycerol and cardiolipin) content of the mitochondria can be varied and controlled in these mutants. This bacterial strain lacks phosphatidylethanolamine (PE) and contains monoglucosyldiacylglycerol. At present, the role of individual phospholipids in specific membrane functions is not c...Wed, 19 Oct 2011 08:27:02 GMTuthsch-otm@uth.tmc.edu with variable beta-tubulin composition, 19 Oct 2011 08:27:01 GMTuthsch-otm@uth.tmc.edu Receptor "Knock out" Mice C5a Receptor "Knock out" Mice The Technology: A researcher at the University of Texas Health Science Center at Houston (UTHealth) has developed complement anaphylatoxin C5a receptor-deficient mice on C57Black6 genetic background via the disruption of the C5aR gene. It is becoming increasingly clear that C5aR plays an important role in the regulation of many physiological and cellular responses characteristic of acute shock and that the C3aR functions to temper the immune response in acute shock. This well-characterized model lacks the complement C5a, making it an excellent model for st...Wed, 19 Oct 2011 08:27:01 GMTuthsch-otm@uth.tmc.edu Receptor "Knock out" Mice C3a Receptor "Knock Out" Mice Market: Global sales of asthma and COPD treatments are currently worth around US$20 billion. In the US asthma affected 29.5 million people in 2005. Asthmatics visited the doctor in offices and outpatient clinics 14.6 million times in 2004, and there were 1.8 million visits to the emergency room. Unfortunately, asthma was the cause of death for 3,780 people in the US in 2004. There is a significant and growing market looking for earlier diagnosis and better treatment options. The Technology: A researcher at the University of Texas Health Science Center at H...Wed, 19 Oct 2011 08:27:00 GMTuthsch-otm@uth.tmc.edu Strain (AD93/pDD72) with Altered Phospholipid Composition for the Production Cardiolipin Bacterial Strain with Altered Phospholipid Composition for the Production of Cardiolipin The Technology: Dr. William Dowhan at the University of Texas Health Science Center at Houston (UTHSC-H) has developed a bacterial strain to construct null mutants in specific steps of phospholipid biosynthesis. The anionic phospholipid (phosphatidylglycerol and cardiolipin) content of the mitochondria can be varied and controlled in these mutants. Cardiolipin is an essential lipid of the mitochondria and until recently has been understudied as to function and regulation of synthesis because of the...Wed, 19 Oct 2011 08:27:00 GMTuthsch-otm@uth.tmc.edu antibodies which recognize specific somastatin receptor subtypes Antipeptide Antibodies That Recognize Specific Somatostatin Receptor Subtypes The Technology: This patent covers: 1. A method for developing somatostatin receptor subtype specific antibodies. 2. Antibodies developed using this method to identify somatostatin receptor subtypes belonging to the seven transmembrane domain receptor family. 3. The use of these antibodies, alone or in kit form, to identify somatostatin receptors in tissues or protein extracts. The utility of the patented technology is founded upon its ability to selectively identify somatostatin receptor subtypes and thus w...Wed, 19 Oct 2011 08:26:59 GMTuthsch-otm@uth.tmc.edu Sentrin Antibody Anti-Sentrin (Sumo-1) Polyclonal Antibody Background: Small Ubiquitin-like Modifier (SUMO) is a family of proteins that modify other proteins by attaching and detaching covalently. SUMO modification of proteins has many functions, including protein stability, nuclear-cytosolic transport, and transcriptional regulation. Such fundamental activities lead to potential market impact in a wide array of fields such as oncology, immunology, and metabolics. The Technology : Dr. Edward Yeh at the University of Texas Health Science Center at Houston (UTHealth) has developed an anti-Sentrin polycl...Wed, 19 Oct 2011 08:26:59 GMTuthsch-otm@uth.tmc.edu Polyclonal Antisera Anti-OPN Polyclonal Antisera The Technology: Researchers at the University of Texas Health Science Center at Houston (UTHSC-H) have developed methods and compositions to analyze and study sialic rich proteins found in osteopontin (OPN), a type of mineralized tissue containing non-collagenous proteins. More specifically, Western immunoblots were performed with anti-OPN polyclonal antisera raised from rabbits. OPN has never been detected in dentin extracts by Western immunoblotting until now, making the antisera an excellent tool for further research into the formation of bone and denti...Wed, 19 Oct 2011 08:26:58 GMTuthsch-otm@uth.tmc.edu NEDD8 Antibody Anti-NEDD8 Monoclonal Antibody Market: Regulation of the cell cycle involves steps that are critical to cell survival, including the detection and repair of genetic damage as well as the prevention of uncontrolled cell division. Studies on the cell cycle impact huge market sectors such as oncology. Background: Neural precursor cell expressed, developmentally down-regulated 8 (NEDD8) is a ubiquitin-like protein that modulates the cullin subunits of SCF ubiquitin E3 ligases. NEDDylation of the cullins is required for recruitment of E2 to the ligase complex, facilitating ubiquitin conjugat...Wed, 19 Oct 2011 08:26:58 GMTuthsch-otm@uth.tmc.edu Deaminase Deficient Transgenic Mice: Testing Ground for Asthma Therapies Adenosine Deaminase Deficient Transgenic Mice and Methods and Uses Thereof Market: Restrictive lung disease, including asthma, SCID, chronic obstructive pulmonary disease (COPD), and pulmonary fibrosis, is a prevalent condition. In the US asthma affected 29.5 million people in 2005. Asthmatics visited the doctor in offices and outpatient clinics 14.6 million times in 2004, and there were 1.8 million visits to the emergency room. Unfortunately, asthma was the cause of death for 3,780 people in the US in 2004. Likewise, COPD, including emphysema and chronic bronchitis, affect many people...Wed, 19 Oct 2011 08:26:57 GMTuthsch-otm@uth.tmc.edu oligonucleotide ligands against endothelial E-selectin protein., 19 Oct 2011 07:45:34 GMTuthsch-otm@uth.tmc.edu to perform Axial-shear strain imaging for tumor classification, 18 Oct 2011 16:04:55 GMTuthsch-otm@uth.tmc.edu of C-Reactive Protein Induced Vascular Inflammation and Their Use Information collected by the Centers for Disease Control and Prevention during 2006 showed that cardiovascular disease (CVD) from all causes accounts for 29% of deaths worldwide and ranks second only to infectious and parasitic diseases. In the United States alone, atherosclerosis reportedly affects one in four persons, causing approximately 42% of all deaths. With a market size of more than $15 billion, the market for novel atherosclerosis therapies has very lucrative potential. Competitors and Current Problems: Inflammatory response plays an important role in the onset, develo...Mon, 22 Aug 2011 16:19:47 GMTuthsch-otm@uth.tmc.edu Highly Sensitive Ultrasound Imaging of Tissue Elasticity In Vivo for Detection and Evaluation of Breast Cancer and Other Elastic Abnormalities Market: Market reports indicate that the ultrasound market in Europe was estimated at $719.0 million in 2006, with growth expected to reach $1 billion in 2013. Similarly, the ultrasound market in the United States was estimated at $1.27 billion in 2003. With an estimated 31.2 million patient exams in 2004 conducted by traditional clinical ultrasound segments alone, in addition to the recent adoption of ultrasound imaging by new user groups including surgeons, anesthesiologists, and emergency physicians, the ultrasound market is expected to continue to spur rapid new growth.Current Prob...Mon, 08 Aug 2011 15:34:50 GMTuthsch-otm@uth.tmc.edu Auto-Focus: Must-have technology for next generation digital cameras, 18 Jul 2011 12:38:11 GMTbrent.schultze@utdallas.edu Charge Injection Tuning of Carbon Nanotube Sheets – Offering Novel Supercapacitor Technology, 06 Jul 2011 11:38:17 GMTbrent.schultze@utdallas.edu Auto Exposure for Digital and Cell Phone Cameras and Imaging Systems, 06 Jul 2011 11:08:08 GMTbrent.schultze@utdallas.edu Carbon Nanotube Assemblies invention is a novel method for processing nanotube powders into polymer-free structures that have superior electrical, mechanical, and electrochemical properties to those of existing polymer-inclusive structures. Flocculation fiber spinning of carbon nanotubes from aqueous dispersions with the aide of polymer-free flocculating agents produces structures such as fibers, ribbons, ropes, yarns and films of carbon nanotubes. As a result, the properties of fibers are determined by carbon nanotubes only; they are not affected by the presence of a polymeric binder.Overcoming limitations on low ...Wed, 06 Jul 2011 11:03:59 GMTbrent.schultze@utdallas.edu Artificial Muscles, 06 Jul 2011 09:39:33 GMTbrent.schultze@utdallas.edu HDAC Inhibitors for the Treatment of Cancers and Sickle Cell Disease, 06 Jul 2011 07:37:56 GMTbrent.schultze@utdallas.edu and Compositions for the Detection of Functional Clostridium Difficile Toxins, 30 Jun 2011 14:03:10 GMTuthsch-otm@uth.tmc.edu and System for Improving SPECT Imaging Resolution, 30 Jun 2011 11:14:49 GMTbrent.schultze@utdallas.edu Tracking System: 21st Century Facilities Management, 30 Jun 2011 11:00:57 GMTbrent.schultze@utdallas.edu Cooperation Diversity in Signal Coding for Wireless Communication invention is a software solution that builds on the concept of user cooperation in wireless communications and displays benefits across virtually all wireless standards and industries. It results in a significant improvement in voice clarity, higher data speeds, and lower transmission power. User coded cooperative wireless communication technology is the latest innovation in which two wireless devices jointly transmit their signals using both of their antennas to diversify the signal that the base station is receiving. By incorporating cooperation with existing error detection and correct...Tue, 28 Jun 2011 14:59:19 GMTbrent.schultze@utdallas.edu and Non-Invasive Imaging of Pancreatic Beta Cells, 10 Jun 2011 09:38:50 GMTbrent.schultze@utdallas.edu Treatment of Inflamed Tissue Market: Coronary artery disease is a leading cause of death in industrialized countries. It is manifested by atherosclerotic plaques, which are thickened areas in vessel walls made up of an accumulation of cholesterol, proliferating smooth muscle cells and inflammatory cells. In 2004, it was reported that over 1 million Americans underwent an angioplasty procedure to correct the build up of these plaques, contributing partly to interventional cardiology market revenue in excess of $4 billion. Competitors and Current Problems: Many techniques have been developed to identify and remove t...Tue, 22 Mar 2011 08:15:07 GMTuthsch-otm@uth.tmc.edu to Prevent Nocturnal Drying of the Oral Cavity, 22 Mar 2011 08:07:39 GMTuthsch-otm@uth.tmc.edu Catheter Insertion System Market: Robotic assisted surgeries are on the rise, up from generally 20,000 robotic assisted procedures in the United States in 2005, to 80,000 robotic assisted prostatectomy procedures alone in 2009. Such robotic assisted surgeries allow for greater precision, smaller incisions and therefore less patient blood loss and quicker patient recovery, but require a highly skilled robotic operator for efficient implementation. Prices of existing surgical systems range from $700,000 to $2.25 million per system, and their presence in hospitals has increased by more than 400% since 2004. Compet...Tue, 22 Mar 2011 08:01:31 GMTuthsch-otm@uth.tmc.edu Proteins from Enterococcal Bacteria, 02 Feb 2011 13:08:22 GMTuthsch-otm@uth.tmc.edu and Method for Palpographic Characterization of Vulnerable Plaque and Other Biological Tissue, 02 Feb 2011 13:08:22 GMTuthsch-otm@uth.tmc.edu Novel Calpain-Like Cysteine Protease in Type 2 Diabetes Market: The World Health Organization (WHO) has estimated that the diabetes 2 market will more than double by 2030. In the United States type 2 diabetes affected 20.8 million people in the year 2000. The number of patients diagnosed with diabetes 2 has been continuously increasing. Approximately 90% of all diabetes cases in the United States are of type 2. With a market size of more than $11.2 billion in the US alone, there is a significant and growing market looking for better treatment options. Competitors and Current Problems: Genome-wide screens for susceptibility genes for complex...Wed, 02 Feb 2011 13:08:21 GMTuthsch-otm@uth.tmc.edu Mouse Models, 19 Oct 2010 07:18:11 GMTuthsch-otm@uth.tmc.edu Monitoring: A Perceptual Chronometer Device and Method for Measuring Fitness-For-Duty (FFD), 19 Oct 2010 07:14:24 GMTuthsch-otm@uth.tmc.edu for Selectively Processing Optical and Other Signals, 05 Aug 2010 15:14:28 GMTbrent.schultze@utdallas.edu and Method for Configuring Optical Circuits, 05 Aug 2010 15:14:27 GMTbrent.schultze@utdallas.edu and Apparatus for Mapping Three-Dimensional Features, 22 Jun 2010 15:46:15 GMTbrent.schultze@utdallas.edu Cell Lines, 18 Jun 2010 07:43:06 GMTsaenzv@uthscsa.edu Method of Storage and Controlled Delivery of Nitric Oxide, 16 Jun 2009 12:11:01 GMTbrent.schultze@utdallas.edu Method of Nitric Oxide Delivery for Healing and Organ Preservation, 18 May 2009 15:16:25 GMTbrent.schultze@utdallas.edu