Search Results - drug+delivery

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Monoclonal Antibodies Binding to Transferrin Receptor (TfR) for Therapeutic Protein Delivery across Blood-Brain Barrier

Blood-brain barrier (BBB) limits brain entry and is one of the major hurdles in developing antibody and protein-based therapeutics for central nervous system (CNS) diseases. UTHealth researchers identified and engineered monoclonal antibodies binding to transferrin receptor (TfR) but not affecting transferrin (Tf) binding to TfR. An engineered monovalent...

Published: 10/21/2024 | Inventor(s): Zhiqiang An

Keywords(s):

Category(s): Drug Delivery, Therapeutics, Neurology/Neurosurgery, Oncology, Biologics

Combination Drug for Preventing Early Hippocampal Synapse Loss and Cognitive Deficits in Alzheimer's Disease

Technology Description: We present a new combination drug for the pharmaceutical treatment of Alzheimer’s Disease (AD) based on our discovery of a novel mechanism of hippocampal vulnerability in AD patients. Hippocampal synaptic injury and neurodegeneration are defining pathological features of the cognitive deficits in Alzheimer's disease...

Published: 1/5/2022 | Inventor(s): Heng Du

Keywords(s):

Category(s): Healthcare, Drug Delivery, Life Sciences, Therapeutics

Formulation of HDACi Loaded ß-Cyclodextrin-poly (ß-amino ester) Nanoparticles

Researchers have developed a novel formulation strategy to encapsulate molecules, including but not limited to histone deacetylase inhibitor (HDACi) drugs in nanoparticle networks composed of beta-cyclodextrin-poly(beta-amino esters). Advantages of this system include high loading capacity, increased in vivo tolerability, sustained release, and improved...

Published: 10/21/2024 | Inventor(s): Rachael Sirianni

Keywords(s):

Category(s): Drug Delivery, Therapeutics, Oncology

Multi-Functional Linking Agent for Imaging and Therapy

MULTI-FUNCTIONAL LINKING AGENT FOR IMAGING AND THERAPYImaging technologies are uniquely positioned to enhance how localized and metastatic tumors are treated. In cases where surgery is indicated, a novel class of imaging agents which combine radioactive of fluorescent tags can be used to improve tumor visualization in real-time. When cancer has spread...

Published: 10/30/2024 | Inventor(s): Ali Azhdarinia

Keywords(s):

Category(s): Diagnostics, Drug Delivery

Di-functional Hyaluronic Acid for Tissue Engineering

Hyaluronic Acid (HA) is a polysaccharide that is expressed in the extracellular matrix (ECM) of all vertebrate tissues, contributing to the development of cells in tissue. HA based hydrogels are useful tools in tissue engineering as the HA can be modified with bioactive peptides to facilitate the growth, differentiation and attachment of stem cells...

Published: 10/21/2024 | Inventor(s): Laura Smith Callahan, Hyun ju Lim

Keywords(s):

Category(s): Drug Delivery, Research Materials, Therapeutics

Nested Nanoparticles for Site-specific, Sequential Drug Delivery

New nested nanoparticles for drug delivery have been developed at UTHealth to deliver multiple drugs in a site-, time-, and sequence-specific manner. These nanoparticles consist of a drug-containing polymeric core made of PLGA, surrounded by an outer shell of cyclodextrin complexed with a second drug. These two delivery components facilitate dual-release...

Published: 10/21/2024 | Inventor(s):

Keywords(s):

Category(s): Drug Delivery