Search Results - drug+delivery

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Monoclonal Antibodies Binding to Transferrin Receptor (TfR) for Therapeutic Protein Delivery across Blood-Brain Barrier

Blood-brain barrier (BBB) limits brain entry and is one of the major hurdles in developing antibody and protein-based therapeutics for central nervous system (CNS) diseases. UTHealth researchers identified and engineered monoclonal antibodies binding to transferrin receptor (TfR) but not affecting transferrin (Tf) binding to TfR. An engineered monovalent...

Published: 1/15/2026 | Inventor(s): Zhiqiang An

Keywords(s):

Category(s): Drug Delivery, Therapeutics, Neurology/Neurosurgery, Oncology, Biologics

Combination Drug for Preventing Early Hippocampal Synapse Loss and Cognitive Deficits in Alzheimer's Disease

Technology Description: We present a new combination drug for the pharmaceutical treatment of Alzheimer’s Disease (AD) based on our discovery of a novel mechanism of hippocampal vulnerability in AD patients. Hippocampal synaptic injury and neurodegeneration are defining pathological features of the cognitive deficits in Alzheimer's disease...

Published: 1/5/2022 | Inventor(s): Heng Du

Keywords(s):

Category(s): Healthcare, Drug Delivery, Life Sciences, Therapeutics

Formulation of HDACi Loaded ß-Cyclodextrin-poly (ß-amino ester) Nanoparticles

Researchers have developed a novel formulation strategy to encapsulate molecules, including but not limited to histone deacetylase inhibitor (HDACi) drugs in nanoparticle networks composed of beta-cyclodextrin-poly(beta-amino esters). Advantages of this system include high loading capacity, increased in vivo tolerability, sustained release, and improved...

Published: 1/15/2026 | Inventor(s): Rachael Sirianni

Keywords(s):

Category(s): Drug Delivery, Therapeutics, Oncology

Multi-Functional Linking Agent for Imaging and Therapy

MULTI-FUNCTIONAL LINKING AGENT FOR IMAGING AND THERAPYImaging technologies are uniquely positioned to enhance how localized and metastatic tumors are treated. In cases where surgery is indicated, a novel class of imaging agents which combine radioactive of fluorescent tags can be used to improve tumor visualization in real-time. When cancer has spread...

Published: 1/15/2026 | Inventor(s): Ali Azhdarinia

Keywords(s):

Category(s): Diagnostics, Drug Delivery