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S100A4 Monoclonal Antibody for Therapeutic and Diagnostic Use

Cancer metastasis are responsible for ~90% of cancer associated deaths. Recent studies suggest that immune cells play critical roles in promoting metastasis, especially myeloid cells from the bone marrow. UTHealth researchers, with researchers from The Methodist Hospital, observed a highly conserved expression of S100A4 in immune suppressive myeloid...

Published: 10/21/2024 | Inventor(s): Zhiqiang An, Ningyan Zhang

Keywords(s):

Category(s): Neurology/Neurosurgery, Oncology, Therapeutics

LILRB2 Monoclonal Antibody for Therapeutic and Diagnostic Uses of Neurodegenerative Diseases

Triggering Receptor Expressed on Myeloid cells 2 (TREM2) plays a key regulatory role in Alzheimer’s disease (AD) by controlling microglia activation and metabolic activities in brain tissues. TREM2 signaling inhibition is mediated by leukocyte immunoglobulin-like receptor subfamily B member 2 (LILRB2). UTHealth inventors created and engineered...

Published: 10/21/2024 | Inventor(s): Zhiqiang An, Ningyan Zhang

Keywords(s):

Category(s): Neurology/Neurosurgery, Therapeutics

Antibodies against CD5L for therapeutic and diagnostic uses

Provided herein are anti-CD5L monoclonal antibodies. Further provided herein are methods of use thereof for the treatment of a disease or disorder, such as cancer. UTHealth Ref. No.: 2020-0016 Inventors: Dr. Zhiqiang An and Dr. Ningyan Zhang at UTHealth; Dr. Anil Sood at UT M.D. Anderson Cancer Center Patent Status: PCT application PCT/US2021/025429...

Published: 10/21/2024 | Inventor(s): Zhiqiang An, Ningyan Zhang, Anil Sood

Keywords(s):

Category(s): Biologics, Oncology, Therapeutics

Monoclonal Antibodies Against PCDH7 for Therapeutic and Diagnostic Use

Non-small cell lung cancer (NSCLC) is the leading cause of cancer-associated deaths worldwide. UTHealth researchers discovered that the cell surface protein Protocadherin 7 (PCDH7) is highly expressed in NSCLC and promotes lung cancer development. Inventors at UTH in collaboration with Dr. O’Donnell’s group at UTSW have discovered a panel...

Published: 10/21/2024 | Inventor(s): Zhiqiang An, Ningyan Zhang, Kathryn O'Donnell

Keywords(s):

Category(s): Diagnostics, Oncology, Therapeutics, Biologics

Monoclonal antibodies against human endotrophin for therapeutic and diagnostic use.

Background Studies have shown that endotrophin, the carboxy-terminal cleavage product of the COL6α3 chain, has potent effects on transformed mammary ductal epithelial cells in rodents. It is abundantly expressed in adipose tissue and is a chemoattractant for macrophages, exerts effects on endothelial cells and enhances the progression through...

Published: 10/21/2024 | Inventor(s): Zhiqiang An, Ningyan Zhang, Philipp Scherer

Keywords(s):

Category(s): Biologics, Oncology, Therapeutics

Monoclonal Antibodies Binding to Transferrin Receptor (TfR) for Therapeutic Protein Delivery across Blood-Brain Barrier

Blood-brain barrier (BBB) limits brain entry and is one of the major hurdles in developing antibody and protein-based therapeutics for central nervous system (CNS) diseases. UTHealth researchers identified and engineered monoclonal antibodies binding to transferrin receptor (TfR) but not affecting transferrin (Tf) binding to TfR. An engineered monovalent...

Published: 10/21/2024 | Inventor(s): Zhiqiang An

Keywords(s):

Category(s): Drug Delivery, Therapeutics, Neurology/Neurosurgery, Oncology, Biologics

TREM2 Monoclonal Antibody for Therapeutic and Diagnostic Use

Triggering Receptor Expressed on Myeloid cells 2 (TREM2) plays a key regulatory role in Alzheimer’s disease (AD) by controlling microglia activation and metabolic activities in brain tissues. Previous studies in rodent models of AD have shown that mice with increased TREM2 expression have reduced amyloid pathology. UTHealth inventors created and...

Published: 10/21/2024 | Inventor(s): Zhiqiang An

Keywords(s):

Category(s): Therapeutics, Diagnostics, Biologics, Neurology/Neurosurgery

Monoclonal Antibodies Against Oncostatin M Receptor (OSMR) for Therapeutic and Diagnostic Use

Researchers from UTHealth and The Medical College of Wisconsin have collaborated to reveal the role of OSMR in promoting ovarian cancer cell proliferation and metastasis through activation of STAT3 signaling, as well as illuminated the preclinical efficacy of antibody-based OSMR targeting for ovarian cancer treatment. More particularly, researchers...

Published: 10/21/2024 | Inventor(s): Zhiqiang An

Keywords(s):

Category(s): Diagnostics, Therapeutics, Biologics, Oncology

Monoclonal Antibodies Against Chitinase 3-like-1 (Chi3l1) for Therapeutic and Diagnostic Use

Researchers at UTHealth have unveiled a critical role of Chi3l1 in hepatic platelet recruitment during acetaminophen (APAP)-induced liver injury (AILI) using murine models of AILI and concanavalin A (Con A)-induced hepatitis. Significantly, they have developed anti-Chi3l1 monoclonal antibodies and demonstrated the feasibility of targeting CHI3L1...

Published: 10/21/2024 | Inventor(s): Zhiqiang An, Changqing (Cynthia) Ju

Keywords(s):

Category(s): Biologics, Therapeutics, Oncology

Pharmacological EZH2 inhibition enhances cancer cell sensitivity to genotoxic insults through suppressing DNA damage repair

HSC-1535 Pharmacological EZH2 inhibition enhances cancer cell sensitivity to genotoxic insults through suppressing DNA damage repairKexin Xu: Department of Molecular Medicine, University of Texas Health Science Center at San Antonio, San Antonio, TX 78229, USA.Myles Brown: Center for Functional Cancer Epigenetics and Department of Medical Oncology,...

Published: 5/28/2024 | Inventor(s): Kexin Xu, Myles Brown, Chen-Hao Chen, Xiaole Shirley Liu, CPRIT

Keywords(s):

Category(s): Clinical Specialty > Oncology, Clinical Specialty > Radiology, Diagnostics > Assay, Life Sciences Research Tools > Biomarkers

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