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Novel Channelrhodopsins for Optogenetics Gene Therapy

When expressed in targeted neurons, light-sensitive channelrhodopsin proteins (ChRs) have the ability to selectively manipulate neuronal activity in a light-dependent manner. Gene therapy using anion ChRs (ACRs) has the potential for treating excessive neuron firing in conditions such as Parkinson’s disease, neuropathic pain and epilepsy, while...

Published: 1/15/2026 | Inventor(s): John Spudich, Elena G Govorunova, Oleg A Sineshchekov

Keywords(s):

Category(s): Therapeutics, Research Materials

Novel Channelrhodopsins for Optogenetics Gene Therapy (KCRs, ACRs, CCRs)

When expressed in targeted neurons, light-sensitive channelrhodopsin proteins (ChRs) have the ability to selectively manipulate neuronal activity in a light-dependent manner. Kalium (potassium)-conducting channelrhodopsins (KCRs) has the potential for optogenetic applications and as therapeutic agents for electrically active cell mediated disorders,...

Published: 1/15/2026 | Inventor(s): John Spudich

Keywords(s):

Category(s): Research Materials, Therapeutics, Neurology/Neurosurgery

LGR4 Specific Monoclonal Antibodies and Their Use

Researchers at UTHealth have isolated and characterized monoclonal antibodies as well as antibody fragments that specifically binding to LGR4, a 7TM receptor that is highly expressed in major types of solid tumors, including but not limited to colorectal cancer, non-small cell lung cancer, and ovarian cancer. These LGR4 specific monoclonal antibodies...

Published: 1/15/2026 | Inventor(s): Qingyun (Jim) Liu

Keywords(s):

Category(s): Biologics, Oncology, Therapeutics, Diagnostics, Research Materials

ebpABC gene deletion mutant TX5608 and E. faecalis strain OG1RF

Endocarditis and biofilm-associated pili (EbpABC) gene deletion of Enterococcus faecalis and WT parent bacteria OG1RF. See published research paper on these bacterial strains: Research paper published:J Clin Invest. 2006 Oct;116(10):2799-807. Endocarditis and biofilm-associated pili of Enterococcus faecalis.Nallapareddy SR, Singh KV, Sillanpää...

Published: 1/15/2026 | Inventor(s):

Keywords(s):

Category(s): Research Materials

Compositions and Methods for Long-Term in Vitro Culture Of The Syphilis Spirochete.

Background Syphilis is a multistage sexually transmitted infection of world-wide importance, with an estimated 5.6 million new cases per year. Treponema pallidum, the causative agent of syphilis, was first identified by Schaudinn and Hoffman in 1905, but in the past researchers have been unable to maintain T. pallidum viability or multiplication beyond...

Published: 1/15/2026 | Inventor(s): Steven Norris, Diane Edmondson

Keywords(s):

Category(s): Diagnostics, Research Materials