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Novel Channelrhodopsins for Optogenetics Gene Therapy (CCRs and KCRs)

When expressed in targeted neurons, light-sensitive channelrhodopsin proteins (ChRs) have the ability to selectively manipulate neuronal activity in a light-dependent manner. Kalium (potassium)-conducting channelrhodopsins (KCRs) have the potential for optogenetic applications and as therapeutic agents for electrically active cell mediated disorders,...

Published: 10/21/2024 | Inventor(s):

Keywords(s):

Category(s): Research Materials, Therapeutics, Neurology/Neurosurgery

LGR4 Specific Monoclonal Antibodies and Their Use

Researchers at UTHealth have isolated and characterized monoclonal antibodies as well as antibody fragments that specifically binding to LGR4, a 7TM receptor that is highly expressed in major types of solid tumors, including but not limited to colorectal cancer, non-small cell lung cancer, and ovarian cancer. These LGR4 specific monoclonal antibodies...

Published: 10/21/2024 | Inventor(s): Qingyun (Jim) Liu

Keywords(s):

Category(s): Biologics, Oncology, Therapeutics, Diagnostics, Research Materials

ebpABC gene deletion mutant TX5608 and E. faecalis strain OG1RF

Endocarditis and biofilm-associated pili (EbpABC) gene deletion of Enterococcus faecalis and WT parent bacteria OG1RF. See published research paper on these bacterial strains: Research paper published:J Clin Invest. 2006 Oct;116(10):2799-807. Endocarditis and biofilm-associated pili of Enterococcus faecalis.Nallapareddy SR, Singh KV, Sillanpää...

Published: 10/21/2024 | Inventor(s):

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Category(s): Research Materials

Compositions and Methods for Long-Term in Vitro Culture Of The Syphilis Spirochete.

Background Syphilis is a multistage sexually transmitted infection of world-wide importance, with an estimated 5.6 million new cases per year. Treponema pallidum, the causative agent of syphilis, was first identified by Schaudinn and Hoffman in 1905, but in the past researchers have been unable to maintain T. pallidum viability or multiplication beyond...

Published: 10/21/2024 | Inventor(s): Steven Norris, Diane Edmondson

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Category(s): Diagnostics, Research Materials

Di-functional Hyaluronic Acid for Tissue Engineering

Hyaluronic Acid (HA) is a polysaccharide that is expressed in the extracellular matrix (ECM) of all vertebrate tissues, contributing to the development of cells in tissue. HA based hydrogels are useful tools in tissue engineering as the HA can be modified with bioactive peptides to facilitate the growth, differentiation and attachment of stem cells...

Published: 10/21/2024 | Inventor(s): Laura Smith Callahan, Hyun ju Lim

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Category(s): Drug Delivery, Research Materials, Therapeutics

Enterotoxigenic Escherichia coli Isolates Identified from Patients with Travelers' Diarrhea

Market: Traveler’s diarrhea is the most common illness affecting travelers, and affects as many as 800 million people a year. The most common causative agent of traveler’s diarrhea is Enterotoxigenic E. coli. Toxins secreted by these bacteria result in severe watery diarrhea. The Technology: Researchers at the University of Texas Health...

Published: 10/21/2024 | Inventor(s):

Keywords(s):

Category(s): Research Materials

Anti-STAM Monoclonal Antibodies

The Technology: Dr. Andrew Bean at the University of Texas Health Science Center at Houston, has developed a monoclonal antibody to STAM. STAM is a protein that plays a role in the movement of proteins into lysosome for degradation. Cellular expression of STAM can be determined using this monoclonal antibody, therefore this antibody will...

Published: 10/21/2024 | Inventor(s):

Keywords(s):

Category(s): Research Materials

Targeting Tumors by Pattern Recognition: A Paradigm shift in Targeted Therapeutics

Market: The American Cancer Society estimates that more than 500,000 people will die from cancer in the U.S. in 2007. Many cancer deaths, specifically from cancers of the colon, breast, rectum, and uterine cervix cancers, could be significantly reduced with earlier detection and improved therapy. Cancer treatment of the 15 most common cancers accounted...

Published: 10/21/2024 | Inventor(s):

Keywords(s):

Category(s): Research Materials, Therapeutics

SUMO-Specific Protease Nucleotides and Proteins for Diagnosing Hyperpoliferative Diseases

Market: Prostate cancer is the second most common cancer, and second leading cause of cancer death, in American men. The American Cancer Society predicts over 186,000 new diagnoses of prostate cancer, and over 28,000 deaths in the US in 2008. With early detection being key to a better prognosis, a significant number of people are demanding faster...

Published: 10/21/2024 | Inventor(s):

Keywords(s): Antibodies, Cancer, Diagnostics, Research tool, Therapeutics

Category(s): Diagnostics, Research Materials, Therapeutics

Structure of Proline- and Arginine-Rich Peptides that Lead to Inhibition of Inflammation and Induction of Angiogenesis

The Technology: PR39, a naturally produced proline-and-arginine-rich peptide consisting of 39 amino acids, induces angiogenesis and reduces inflammation in mouse models. Through structural and biochemical investigations of PR11, a truncated form of PR39, researchers at the University of Texas Health Science Center at Houston (UTHSC-H) have...

Published: 10/21/2024 | Inventor(s):

Keywords(s):

Category(s): Research Materials, Therapeutics

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