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Novel Channelrhodopsins for Optogenetics Gene Therapy

When expressed in targeted neurons, light-sensitive channelrhodopsin proteins (ChRs) have the ability to selectively manipulate neuronal activity in a light-dependent manner. Gene therapy using anion ChRs (ACRs) has the potential for treating excessive neuron firing in conditions such as Parkinson’s disease, neuropathic pain and epilepsy, while...

Published: 1/15/2026 | Inventor(s): John Spudich, Elena G Govorunova, Oleg A Sineshchekov

Keywords(s):

Category(s): Therapeutics, Research Materials

Novel Channelrhodopsins for Optogenetics Gene Therapy (KCRs, ACRs, CCRs)

When expressed in targeted neurons, light-sensitive channelrhodopsin proteins (ChRs) have the ability to selectively manipulate neuronal activity in a light-dependent manner. Kalium (potassium)-conducting channelrhodopsins (KCRs) has the potential for optogenetic applications and as therapeutic agents for electrically active cell mediated disorders,...

Published: 1/15/2026 | Inventor(s): John Spudich

Keywords(s):

Category(s): Research Materials, Therapeutics, Neurology/Neurosurgery