Search Results - qingyun+(jim)+liu

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LGR4 Specific Monoclonal Antibodies and Their Use

Researchers at UTHealth have isolated and characterized monoclonal antibodies as well as antibody fragments that specifically binding to LGR4, a 7TM receptor that is highly expressed in major types of solid tumors, including but not limited to colorectal cancer, non-small cell lung cancer, and ovarian cancer. These LGR4 specific monoclonal antibodies...

Published: 10/21/2024 | Inventor(s): Qingyun (Jim) Liu

Keywords(s):

Category(s): Biologics, Oncology, Therapeutics, Diagnostics, Research Materials

R-Spondin Polypeptides and Drug Conjugates for Cancer Treatment

R-spondins (RSPOs) are secreted proteins with critical roles in cancer development through binding to LGR4/5/6 and RNF43/ZNRF3 and potentiating Wnt signaling. UTHealth pioneering scientist engineered and fused an immunoglobin Fc domain to the mutated RSPOs (RSPO peptibodies). RSPO peptibodies can binds to LGR4/5/6 with high affinity but exhibit reduced...

Published: 10/21/2024 | Inventor(s): Qingyun (Jim) Liu

Keywords(s):

Category(s): Biologics, Oncology, Therapeutics

System for Selectively Labeling RNA

The invention pertains to a three step initiation, elongation and termination method and platform for synthesizing selectively labeled RNA molecules by first polymerizing a first liquid phase RNA molecule from a solid phased DNA template fixed onto a solid phase. Background:The method includes the steps of incubating the solid and liquid phases at appropriate...

Published: 5/22/2024 | Inventor(s): Rui Sousa, Yun-Xing Wang, Liu Yu, Ping Yu

Keywords(s):

Category(s): Life Sciences Research Tools > Genomics