Search Results - Therapeutics+%3e+Small+Molecule

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Prevention of epileptic seizures by targeting canonical transient receptor potential (TRPC) channels in the brain

10 mg/kg (i.p.) M084 hydrochloride was administered 30 minutes prior to a widely used model of seizure induction in mice (pilocarpine-induced seizure). The TRPC channel antagonist significantly blocked seizure activity, compared to vehicle-injected control animals. We will investigate TRPC channel block for control of seizures in multiple mouse models...

Published: 8/22/2024 | Inventor(s): Chase Carver

Keywords(s):

Category(s): Clinical Specialty > Neurology, Therapeutics > Small Molecule

Oxytocin to prevent, reduce and reverse Opioid-Induced Respiratory Depression

Opioid-induced respiratory depression is the primary cause of death due to overdose. Opioid antagonism by naloxone (Narcan), the only FDA-approved drug to treat opioid overdose, causes severe withdrawal related pain and stress in resuscitation patients. Therefore, there is a desperate need for drug targets that counter respiratory depression by opioids...

Published: 5/22/2024 | Inventor(s): Glenn Toney, Allison Brackley

Keywords(s):

Category(s): Clinical Specialty > Pulmonology, Clinical Specialty > Pain Management, Clinical Specialty > Sleep Disorders, Clinical Specialty > Ear, Nose, Throat, Therapeutics > Analgesics, Therapeutics > Small Molecule

An improved muscarinic-antagonist antidepressant

Scopolamine, a non-selective muscarinic antagonist, is a rapidly effective antidepressant compoundin humans likely mediated through an antimuscarinic effect. Unfortunately, scopolamine canproduce cognitive impairment including memory disturbances in humans. It is our goal to identifya muscarinic antagonist that may be able to relieve depression without...

Published: 5/5/2021 | Inventor(s): James Woods, Andrew Coop, Chad Johnson, Jack Bergman, Emily Jutkiewicz, Brian Kangas

Keywords(s):

Category(s): Clinical Specialty > Psychiatry, Therapeutics > Small Molecule

New approach for treating functional dyspepsia

My inventive idea is to use a therapeutic molecule that slows gastric emptying for the treatment of functional dyspepsia in non-diabetic patients. This contrarian idea is based on our research of gastric emptying which shows that 30% of non-diabetic patients referred for gastric emptying studies due to gastrointestinal symptoms have elevated postprandial...

Published: 12/7/2023 | Inventor(s): William Phillips

Keywords(s):

Category(s): Clinical Specialty > Gastroenterology, Food Science > Nutrition, Therapeutics > Small Molecule

Pharmacological manipulation of M-type (KCNQ, Kv7) potassium currents as a therapeutic target for treatment of addiction

Members of KCNQ2-5 (Kv7.2-7.5) K+ channel subunits underlie the neuronal M-type K+ current, a critical regulator of neuronal excitability, including resting membrane potential, threshold excitability and spike bursting. Inhibition of M-type channels is excitatory, whereas their augmentation usually has an inhibitory, silencing effect. M current has...

Published: 9/14/2023 | Inventor(s): Fabio Antonio Borges Vigil, Mark Shapiro

Keywords(s):

Category(s): Clinical Specialty > Neurology, Clinical Specialty > Psychology, Therapeutics > Small Molecule

Dopamine 2 Receptor agonists as new therapeutics for Age Related Macular Degeneration and Diabetic Retinopathy

By understanding and controlling activation of specific dopamine receptors, we showed that the current dopamine pathway drugs can be used in new ways as new therapeutics to treat wet age-related macular degeneration (ARMD) and diabetic retinopathy (DR). It will reduce the chance of a side effect of conventional ARMD or DR therapy, leading to vision...

Published: 6/4/2021 | Inventor(s): Jeong-Hyeon Sohn, Rene Renteria, Nikolay Akimov

Keywords(s):

Category(s): Clinical Specialty > Opthamology, Therapeutics > Small Molecule

CsA treatment for BRCA1 mutant cancers

I have demonstrated that BRCA1-mutant triple-negative breast cancer (TNBC) cells are highly sensitive to cyclosporine (CsA) and non-immunosuppressive CsA-derivatives (NIM811 or Alisporivir). To determine whether CsA would also be effective in treating BRCA1-mutant TNBC cells in vivo, I set up a pilot study using a preclinical xenograft model to investigate...

Published: 10/5/2021 | Inventor(s): Kimi Yuk-Ling Kong

Keywords(s):

Category(s): Clinical Specialty > Oncology, Clinical Specialty > Women's Health, Clinical Specialty > Endocrinology, Life Sciences Research Tools > Drug Screening, Therapeutics > Small Molecule

A new approach for treatment of liver cancers

The early stage of hepatocellular carinoma (HCC) tumors (<5cm) can either be excised surgically, or removed byablation therapy, but treatment of advanced stage HCC remain challegning. Since, HCC and other liver cancersare diagnosed at advanced stage, their surgical excision is not feasible. The existing front- and second-linetherapies for advanced...

Published: 9/14/2023 | Inventor(s): Yogesh Gupta

Keywords(s):

Category(s): Clinical Specialty > Oncology, Life Sciences Research Tools > Drug Screening, Therapeutics > Small Molecule, Clinical Specialty > Hepatology

Gene Transfer to Improve Cognitive Dysfunction in Alzheimer’s Disease

University of Texas Health Science Center at San Antonio researchers have developed a unique therapeutic approach which could restore learning and memory ability in those afflicted with Alzheimer’s Disease and other neurodegenerative diseases. Abnormalities in the expression of cAMP-response element binding protein (CREB) have been reported in...

Published: 1/16/2019 | Inventor(s): Salvatore Oddo, Antonella Caccamo

Keywords(s):

Category(s): Clinical Specialty > Neurology, Therapeutics > Small Molecule

PARP-1 Inhibitor Nanoparticle and Treatment Method for Ewing Sarcoma

A novel nanoparticle formulation of an existing PARP-1 inhibitor and an associated administration regimen has been developed for the treatment of Ewing Sarcoma. This technology allows the therapeutic treatment to be targeted to the tumors, resulting in reduced required doses and system toxicity.Background:Ewing Sarcoma is rare cancer of the bone that...

Published: 5/14/2024 | Inventor(s): Raushan Kurmasheva, Kytai Nguyen

Keywords(s):

Category(s): Clinical Specialty > Orphan Diseases, Clinical Specialty > Orthopedics, Therapeutics > Nanoparticles, Clinical Specialty > Oncology, Therapeutics > Small Molecule

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